发明名称 |
Novel Benzopyran Compounds, Compositions and Uses Thereof |
摘要 |
Benzopyran compounds with strong anti-estrogenic activity and essentially no estrogenic activity are provided, which are OP-1038, which is 3-(4-hydroxyphenyl)-4-methyl-2-(4-{2-[(3R)-3-methylpyrrolidin-1-yl]ethoxy}phenyl)-2H-chromen-7-ol, and OP-1074, which is (2S)-3-(4-hydroxyphenyl)-4-methyl-2-(4-{2-[(3R)-3-methylpyrrolidin-1-yl]ethoxy}phenyl)-2H-chromen-7-ol. OP-1074 is a pure anti-estrogen when tested in the agonist mode and a complete anti-estrogen when tested in the antagonist mode. These compounds are useful for the treatment or prevention of a variety of conditions that are modulated through the estrogen receptor in mammals including humans.
|
申请公布号 |
US2013178445(A1) |
申请公布日期 |
2013.07.11 |
申请号 |
US201213717326 |
申请日期 |
2012.12.17 |
申请人 |
OLEMA PHARMACEUTICALS, INC.;OLEMA PHARMACEUTICALS, INC. |
发明人 |
KUSHNER PETER J.;MYLES DAVID C.;HARMON CYRUS L.;GALLAGHER LESLIE CAROL HODGES |
分类号 |
A61K31/4025;A61K31/565;A61K31/675;A61K45/06;C07D405/12;C07F9/6558 |
主分类号 |
A61K31/4025 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|