发明名称 |
METHODS AND COMPOSITIONS FOR IMMUNOTHERAPY AND DETECTION OF INFLAMMATORY AND IMMUNE-DYSREGULATORY DISEASE, INFECTIOUS DISEASE, PATHOLOGIC ANGIOGENESIS AND CANCER |
摘要 |
Methods and compositions for immunotherapy of inflammatory and immune-dysregulatory diseases, using multispecific antagonists that target at least two different markers are disclosed. The different targets include proinflammatory effectors of the innate immune system and targets specifically associated with an inflammatory or immune-dysregulatory disorder, wherein the targets included in the latter group are not a proinflammatory effector of the immune system. Thus, the multispecific antagonist contains at least one binding specificity related to the diseased cell or condition being treated and at least one specificity to a component of the immune system. The multispecific antagonists are used in the treatment of various diseases that are generated or exacerbated by, or otherwise involve, proinflammatory effectors of the innate immune system.
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申请公布号 |
US2013177498(A1) |
申请公布日期 |
2013.07.11 |
申请号 |
US201213678832 |
申请日期 |
2012.11.16 |
申请人 |
IMMUNOMEDICS, INC.;IMMUNOMEDICS, INC. |
发明人 |
GOLDENBERG DAVID M.;HANSEN HANS J. |
分类号 |
A61K39/395;A61K31/513;A61K38/19;A61K38/20;A61K38/48;A61K39/40;A61K45/06 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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