IGFBP-5, A MARKER FOR DIAGNOSING RADIATION EXPOSURE, A COMPOSITION FOR DIAGNOSING RADIATION EXPOSURE TO MEASURE THE LEVEL OF EXPRESSION OF THE MARKER, A KIT FOR DIAGNOSING RADIATION EXPOSURE COMPRISING THE COMPOSITION, AND A METHOD FOR DIAGNOSING RADIATION EXPOSURE USING THE MARKER

摘要

PURPOSE: A composition containing an agent which measures expression level of insulin-like growth factor binding protein 5 (IGFVP-5) mRNA or protein for diagnosing radiation exposure, and a kit containing the composition for diagnosing radiation exposure are provided to diagnose radiation exposure or exposure level, and to screen radiation sensitivity enhancers by selecting materials which increase expression level of IGFBP-5 mRNA or protein. CONSTITUTION: A composition for diagnosing radiation exposure contains an agent which measures expression level of IGFBP-5 mRNA or protein. A kit for diagnosing radiation exposure contains the composition. A method for diagnosing radiation exposure comprises the steps of: measuring expression level of IGFBP-5 mRNA or protein in a patient's sample; comparing the measured expression level with a normal control group; and determining radiation exposure when the expression level in the patient's sample is higher than the normal control group.