发明名称 |
MODIFIED 5'- PHOSPHONATE AZIDOTHYMIDINE-POTENTIAL ANTI-VIRAL PREPARATIONS |
摘要 |
<p>The invention relates to the field of molecular biology, virology and medicine and, more specifically, to novel derivatives of 3'-azido-3'-deoxythymidine phosphonates with the following general formula
where R = alkyl groups, including those containing halogen atoms, carboxy-, hydroxy-, alkoxy- and acyloxy- groups as well as substituted aminocarbonyl groups. The compounds can be used as antiviral agents as they have low toxicity and can effectively inhibit replication of type 1 immunodeficiency virus in MT-4 cell culture and generate AZT in mammalians ensuring a gradual increase of its concentration in the blood.</p> |
申请公布号 |
EP1829885(A4) |
申请公布日期 |
2013.07.10 |
申请号 |
EP20050763842 |
申请日期 |
2005.05.06 |
申请人 |
KUKHANOVA, MARINA KOSTANTINOVNA |
发明人 |
KHANDAJINSKAYA, ANASTASIYA, LVOVNA;YASKO, MAXIM VLADIMIROVICH;SHIROKOVA, ELENA ANATOLIEVNA;SHIPITSYN, ALEXANDER V.;POKROVSKY, ANDREY GEORGIEVICH |
分类号 |
C07H19/10;A61K31/70;A61P31/12;A61P31/18 |
主分类号 |
C07H19/10 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|