AGLYCOSYLATED HUMAN ANTIBODY AND FUSION PROTEIN AND USES THEREOF

摘要

The invention is a method for reducing the effector functions of a therapeutic neutralizing antibody by administering to the afflicted subject an effective amount of an engineered aglycosylated human monoclonal antibody containing an engineered Fc region, wherein aglycosylation of the Fc region prevents therapeutic antibody-mediated cell activation, inflammation, Clq binding to the antibody and antibody triggered classical pathway activation.