发明名称 METHOD OF PREPARING NERAMEXANE
摘要 The method of producing a salt of 1-amino-1,3,3,5,5-pentamethylcyclohexane comprising steps (i) to (v): (i) converting isophorone to 3,3,5,5-tetramethylcyclohexanone; (ii) converting 3,3,5,5-tetramethylcyclohexanone obtained in step (i) to 1-hydroxy-1,3,3,5,5-pentamethylcyclohexane; (iii) converting 1-hydroxy-1,3,3,5,5-pentamethylcyclohexane obtained in step (ii) to 1-chloroacetamido-1,3,3,5,5-pentamethylcyclohexane; (iv) converting 1-chloroacetamido-1,3,3,5,5-pentamethylcyclohexane obtained in step (iii) to 1-amino-1,3,3,5,5-pentamethylcyclohexane; wherein at least one of 3,3,5,5-tetramethylcyclohexanone, 1-hydroxy-1,3,3,5,5-pentamethylcyclohexane, 1-chloroacetamido-1,3,3,5,5-pentamethylcyclohexane, is not subjected to a purification step.
申请公布号 HRP20130486(T1) 申请公布日期 2013.06.30
申请号 HR2013P000486T 申请日期 2013.06.04
申请人 MERZ PHARMA GMBH & CO. KGAA 发明人 KOLLER, HERBERT;PYERIN, MICHAEL;SBROGIò, FEDERICO
分类号 C07C209/62;C07C209/16;C07C211/35 主分类号 C07C209/62
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