| 摘要 |
593090 The present disclosure provides azaquinolinone derivatives and methods for treating or preventing the development of a disease, disorder, or condition associated with proteinopathy in a subject or patient. Compounds of the disclosure include: 6-((4-chlorophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-methoxypheny1)-1-methyl-1,8-naphthyridin-2(1H)-one, 6(R)-(amino(4-ehlorophenyl)(1-methyl-1H-imidazol-5-y1)methyl)-4-(3-methoxypheny1)-1-methyl-1,8-naphthyridin-2(1H)-one and 6(S)-(amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-methoxyphenyl)-1-methyl-1,8-naphthyridin-2(1H)-one and 6((4-chlorophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-ethynylpheny1)-1-methyl-1,8-naphthyridin-2(1H)-one
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