发明名称 |
METHOD OF PRODUCTION OF RECOMBINANT GLYCOPROTEINS WITH INCREASED CIRCULATORY HALF-LIFE IN MAMMALIAN CELLS |
摘要 |
Provided herein are methods and recombinant expression systems for the production of recombinant glycoproteins that have increased sialic acid content and contain predominantly alpha2-6 sialic acid linkages. Also provided herein are recombinant glycoproteins that have an increased in vivo circulatory half-life. One potential application of the glycoproteins described herein is for the treatment and prophylaxis of poisoning by neurotoxins. |
申请公布号 |
SG190260(A1) |
申请公布日期 |
2013.06.28 |
申请号 |
SG20130036694 |
申请日期 |
2012.01.06 |
申请人 |
THE JOHNS HOPKINS UNIVERSITY |
发明人 |
BETENBAUGH, MICHAEL, J. |
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