| 摘要 |
FIELD: chemistry.SUBSTANCE: disclosed are versions of a method based on a specially designed algorithm for assessing the deprivation action of 1,4-butane diol, thiopental and sodium oxybutyrate. The algorithm comprises 5 steps: determining the average lethal dose for the substance, describing the clinical presentation of intoxication with evaluation of neurological parameters and vital functions during intoxication in a wide range of doses, creating an array of data obtained when evaluating neurological parameters and vital functions, conducting statistical processing and constructing a mathematical model. Based on that, a coma depth index is calculated for each specific case.EFFECT: method provides high accuracy of determining severity of damage and extent of deprivation action of chemical substances with simple and highly reliable prediction of the result of intoxication, which can be used to optimise search for pathogenetic intoxication therapy agents.3 cl, 3 ex |
