发明名称 |
METHODS FOR ENHANCING IMMUNE RESPONSE |
摘要 |
This disclosure demonstrates a novel therapy immunological approach using polyamine-based therapy (PBT) for relieving tumor-induced suppression of the patient's immune system. The demonstration of the pharmacological release from the naturally occurring polyamine-mediated immune suppression offers profound impact on the immunotherapy of cancer together with a variety of diseases caused by the disease-causing vector's ability to evade an immune reaction. This therapeutic approach is equally applicable to disease states whereby immune system suppression by polyamines has been demonstrated including; bacterial infections, parasitic infections including malaria and typanosomiasis, viral infections, peptic ulcers and gastric cancer due to H. Pylori infection together with prevention of pregnancy. With a small molecule drug, used in combination with DFMO, the pharmacological manipulation of polyamine levels for therapeutic benefit in various disease states is possible.
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申请公布号 |
US2013164328(A1) |
申请公布日期 |
2013.06.27 |
申请号 |
US201313771799 |
申请日期 |
2013.02.20 |
申请人 |
AMINEX THERAPEUTICS;LANKENAU INSTITUTE FOR MEDICAL RESEARCH;LANKENAU INSTITUTE FOR MEDICAL RESEARCH;AMINEX THERAPEUTICS |
发明人 |
BURNS MARK R.;GILMOUR SUSAN K.;O'BRIEN THOMAS G. |
分类号 |
A61K39/21;A61K39/00;A61K39/02;A61K39/145;A61K45/00 |
主分类号 |
A61K39/21 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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