CRYSTALLINE MINOCYCLINE THERMO-RESISTANT OBTAINED BY RECRYSTALLIZATION WITH CARBON DIOXIDE

摘要

The present invention relates to a novel form of minocycline chlorohydrate characterized in that- it is crystalline and it presents characteristic powder X-ray diffraction pattern and infrared spectrum. This new polymorph constitutes the most stable form of minocycline with a melting point much higher than that of other known crystalline forms of minocycline. The process of production of this new minocycline polymorphic form consists in the dissolution of carbon dioxide in solutions or suspensions of minocycline chlorohydrate with organic solvents, under certain conditions of pressure and temperature. The present invention places minocycline in the restrict group of antibiotics with a melting temperature higher than the sterilization temperature, which enhances new applications and allows the optimization of production at industrial