| 摘要 |
<p>PURPOSE: A method for preparing triazolylcoumarin derivatives with novel fluorous alkyl groups is provided to enable fixation, fixation monitoring, and organic low molecular compound attachment. CONSTITUTION: A triazolylcoumarin derivative is denoted by chemical formula 1. In chemical formula 1: A, B, and D are alkylene group of 1-6 carbon atoms; a is 5-9 integer; and b is 2-5 integer. A method for preparing the derivative comprises: a step of reacting methyl 7-ethynyl coumarin-4-acetate of chemical formula 2 with azide with the fluorous alkyl group of chemical formula 3 to prepare 7-triazolyl coumarin-4-acetate of chemical formula 4; a step of ester hydrolysis of the compound of chemical formula 4 to prepare a fluorous alkyl group-substituted 7-triazolyl coumarin-4-acetic acid of chemical formula 5; a step of reacting the compound of chemical formula 5 with diamine with a protection group of chemical formula 6 to prepare fluorous alkyl group-substituted 7-triazolyl coumarin-4-acetamide; and a step of deprotecting the compound of chemical formula 7 to prepare triazolylcoumarin of chemical formula 1.</p> |
