发明名称 |
Method for preparing of monodisperse oligo ethylene glycol |
摘要 |
The invention provides small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer obtained from a monodisperse or bimodal water-soluble oligomer composition. A conjugate of the invention, when administered by any of a number of administration routes, exhibits a reduced biological membrane crossing rate as compared to the biological membrane crossing rate of the small molecule drug not attached to the water-soluble oligomer. |
申请公布号 |
EP2604282(A1) |
申请公布日期 |
2013.06.19 |
申请号 |
EP20120192296 |
申请日期 |
2004.12.16 |
申请人 |
NEKTAR THERAPEUTICS |
发明人 |
BENTLEY, MICHAEL D.;VIEGAS, TACEY X.;GOODIN, RICHARD R.;CHENG, LIN;ZHAO, XUAN |
分类号 |
A61K47/48;A61K31/765;A61K31/785;C08G65/08;C08G65/329;C08G65/337;C08G65/34 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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