发明名称 |
RECOMBINANT PROTEIN FOR INTRACELLULAR DELIVERY OF siRNA AND COMPOSITION COMPRISING THE SAME |
摘要 |
The present invention relates to a recombinant protein for siRNA delivery, which allows the efficient intracellular and in vivo delivery of siRNA. More particularly, the present invention relates to a recombinant protein that allows a siRNA binding protein to be located in the interior cavity of a capsid protein of HBV (Hepatitis B virus), in which siRNAs of interest bind to the siRNA binding protein to be encapsulated within the capsid shell, thereby providing stability against the external attack such as nucleases and achieving the efficient intracellular and in vivo delivery of siRNA by its release into the cytosolic space after cell uptake. |
申请公布号 |
US2013150287(A1) |
申请公布日期 |
2013.06.13 |
申请号 |
US201113313580 |
申请日期 |
2011.12.07 |
申请人 |
AHN HYUNG-JUN;KWON ICK-CHAN;CHOI KUI-WON;KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY |
发明人 |
AHN HYUNG-JUN;KWON ICK-CHAN;CHOI KUI-WON |
分类号 |
A61K47/48;A61P25/28;A61P27/02;A61P31/12;A61P35/00;C07K19/00 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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