RNA APTAMERS FOR E.COLI O157:H7

摘要

PURPOSE: An RNA aptamer is provided to detect E.coli O157:H7 by specifically binding to E.coli O157:H7, to prevent E.coli O157:H7, and to prevent food spoilage. CONSTITUTION: An RNA aptamer has a base sequence selected from a group consisting of sequence numbers 1-4, which specifically binds to E.coli O157:H7. Urecil(U) and cytosine(C) of sequence number 1 or 2 have 2' hydroxyl group which is substituted with a fluorine group. A biosensor for detecting E.coli O157:H7 contains the RNA aptamer. A pharmaceutical composition for preventing or treating diseases selected from a group consisting of food poisoning, hemolytic uremic syndrome(HUS), and hemolytic anemia contains the RNA aptamer. A food additive composition contains the RNA aptamer.