发明名称 |
CRYSTALLINE FORMS OF THE TRI-MESYLATE SALT OF PERPHENAZINE-GABA AND PROCESS OF PRODUCING THE SAME |
摘要 |
Novel crystalline form of perphenazine 4-aminobutyrate trimesylate and a process of producing the same are disclosed. The novel crystalline form is characterized by a unique XRPD pattern and a DSC that exhibits an endothermic peak at a relatively high temperature (e.g., higher than 209° C.). Also disclosed are a process of preparing perphenazine 4-aminobutyrate trimesylate by in situ deprotection and salification, in a single-step synthesis, and a highly pure perphenazine 4-aminobutyrate trimesylate obtained thereby. Uses of any of the described perphenazine 4-aminobutyrate trimesylate are also disclosed.
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申请公布号 |
US2013150352(A1) |
申请公布日期 |
2013.06.13 |
申请号 |
US201313763815 |
申请日期 |
2013.02.11 |
申请人 |
RAMOT AT TEL-AVIV UNIVERSITY LTD.;BAR-ILAN UNIVERSITY;BIOLINERX LTD.;RAMOT AT TEL-AVIV UNIVERSITY LTD.;BIOLINERX LTD.;BAR-ILAN UNIVERSITY |
发明人 |
NUDELMAN ABRAHAM;REPHAELI ADA;GIL-AD IRIT;WEIZMAN ABRAHAM;SHAUL MAZAL;HALBFINGER EFRAT |
分类号 |
C07D417/06 |
主分类号 |
C07D417/06 |
代理机构 |
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