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发明名称
β-蒿甲醚的工业化定向合成
摘要
本发明以青蒿素为原料一锅法定向合成β-蒿甲醚。在二氯甲烷碱性水溶液体系,以硼氢化钠作为还原剂、叔丁氧基铝催化剂,还原得到的双氢青蒿素。分出水相,加入甲醇与硫酸氢钠、高氯酸铝、高氯酸镍等作为甲醚化反应的催化剂,室温反应2h得到β-蒿甲醚,产率最高为85%,蒿甲醚总产率最高为93.5%。该方法具有成本低、产率高、时间短、操作简单安全的特点,完全适用于工业化大生产。
申请公布号
CN103145728A
申请公布日期
2013.06.12
申请号
CN201310125298.4
申请日期
2013.04.12
申请人
张梅
发明人
张梅
分类号
C07D493/20(2006.01)I
主分类号
C07D493/20(2006.01)I
代理机构
代理人
主权项
一种制备蒿甲醚的中间体双氢青蒿素的方法,其特征为向青蒿素的二氯甲烷(或氯仿)溶液滴加含少量氢氧化钠的硼氢化钠溶液。
地址
215634 江苏省张家港市保税区广东路7号D栋
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