ANALOGUES OF BENZOQUINONE-CONTAINING ANSAMYCINS (VERSIONS), METHOD FOR PRODUCTION THEREOF, PHARMACEUTICAL COMPOSITION (VERSIONS) AND CANCER TREATMENT METHOD (VERSIONS)

摘要

FIELD: chemistry.SUBSTANCE: invention relates to analogues of benzoquinone-containing ansamycins of formulaeand,in which radicals and symbols assume values given in the claim, and use thereof to treat and modulate proliferation-associated disorders such as cancer. The present invention describes a method of producing analogues of benzoquinone-containing ansamycins according to which benzoquinone is reduced to hydroquinone and bonded through reaction with a suitable acid.EFFECT: high solubility and air stability of the obtained ammonium hydroquinone ansamycin analogue.181 cl, 70 dwg, 38 ex