发明名称 |
DEVICES AND METHODS FOR INTEGRATED CONTINUOUS MANUFACTURING OF BIOLOGICAL MOLECULES |
摘要 |
The present invention relates to a process and apparatus for purifying a molecule of interest from a heterogeneous clarified fluid mixture. The apparatus of the invention generally comprises a continuous perfusion fermentation system, a continuous particle removal system integrated with the perfusion fermentation system; and a continuous purification system integrated with the particle removal system, which is maintained under sterile conditions. The process comprises filtering a heterogeneous clarified fluid mixture by continuous ultrafiltration at a specific flow rate below the transition point of the molecule of interest in the pressure-dependent region of the flux versus TMP curve, wherein the specific flow rate is maintained substantially constant throughout the continuous ultrafiltration. |
申请公布号 |
HK1110519(A1) |
申请公布日期 |
2013.06.07 |
申请号 |
HK20080104831 |
申请日期 |
2008.05.02 |
申请人 |
BAYER HEALTHCARE LLC |
发明人 |
VOGEL, JENS;GIOVANNINI, ROBERTO;KONSTANTINOV, KONSTANTIN, B.;NGUYEN, HUONG;WU, PENG |
分类号 |
A61K;B01D;B07B |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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