发明名称 |
Acid Salt Forms of Polymer-Drug Conjugates and Alkoxylation Methods |
摘要 |
Among other aspects, provided herein is a mixed-acid salt of a water-soluble polymer-drug conjugate, along with related methods of making and using the same. The mixed-salt acid salt is stably formed, and appears to be more resistant to hydrolytic degradation than the corresponding predominantly pure acid salt or free base forms of the polymer-drug conjugate. The mixed acid salt is reproducibly prepared and recovered, and provides surprising advantages over non-mixed acid salt forms of the water-soluble polymer drug conjugate. |
申请公布号 |
US2013143909(A1) |
申请公布日期 |
2013.06.06 |
申请号 |
US201013510555 |
申请日期 |
2010.11.18 |
申请人 |
CHONG ANTHONY O.;LEE SEOJU;JOSHI BHALCHANDRA V.;BRAY BRIAN;NIE SHAOYONG;SPENCE PATRICK L.;KOZLOWSKI ANTONI;MCMANUS SAMUEL P.;TIPNIS SACHIN;LAVATY GREG;SWALLOW DAVID;HANDLEY JOHN R.;SCHAEFER ANTHONY G.;NEKTAR THERAPEUTICS |
发明人 |
CHONG ANTHONY O.;LEE SEOJU;JOSHI BHALCHANDRA V.;BRAY BRIAN;NIE SHAOYONG;SPENCE PATRICK L.;KOZLOWSKI ANTONI;MCMANUS SAMUEL P.;TIPNIS SACHIN;LAVATY GREG;SWALLOW DAVID;HANDLEY JOHN R.;SCHAEFER ANTHONY G. |
分类号 |
C08G65/48;A61K47/48;C07C51/41;C07C53/18 |
主分类号 |
C08G65/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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