OPTICAL ACTIVITY FLUORINE-CONTAINING &bgr;-AMINO ACID DERIVATIVE, AND PRODUCTION METHOD OF THE SAME

摘要

PROBLEM TO BE SOLVED: To provide: a novel optical activity fluorine-containing β-amino acid derivative useful as the synthetic intermediate of a medicine and pesticide; a manufacturing method of the same; and a manufacturing method of a trifluoromethyl group-containing β-amino acid derivative.

SOLUTION: Optical activity trifluoromethyl(t-butyl sulfine imine) and malonic acids are made to react in the presence of a base catalyst, thereby an optical activity fluorine-containing β-amino acid derivative of formula (1) is obtained and is performed by the processing of an acid to be a trifluoromethyl group-containing β-amino acid derivative. In the formula, R1denotes a hydrogen atom, an alkyl group or the like, R2denotes a hydrogen atom, an alkyl group or the like, and * denotes asymmetric carbon.

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