2-AMINATED METHYLENE OR 2-ESTERIFIED METHYLENE TANSHINONE DERIVATIVES, AND PREPARATION METHOD AND APPLICATION THEREOF

摘要

The present invention relates to the field of natural drugs and pharmaceutical chemistry, and more particularly to novel 2-aminated methylene or 2-esterified methylene tanshinone I derivatives of a general formula I or pharmaceutically acceptable salts thereof, a method for preparing such compounds, a pharmaceutical composition containing the compound, and a use thereof in preparation of antitumor drugs. In the formula I, when X is nitrogen, the derivative is 2-aminated methylene tanshinone I. When X is oxygen, the derivative is 2-esterified methylene tanshinone I.