摘要 |
The present invention relates to a new class of 5-aryl-5H-pyrrolo[3,2-d]pyrimidin-4-amines which contain 6,7-fused cycloalkyl and heterocycloalkyl ring systems. Compounds of this class have been found to be effective inhibitors of protein kinases: including members of the SRC and Tec kinase families. These compounds demonstrate the requisite physiochemical properties for use as pharmaceutical agents for the treatment of various proliferative, inflammatory and autoimmune diseases such as, but not limited to, cancer, arthritis, MS and the like. |