发明名称 N-ARYLYLMETHYLINDAZOLE MODULATORS OF PPARG
摘要 <p>The invention provides molecular entities that bind with high affinity to PPARG (PPARy), inhibit cdJk5-mediated phosphorylation of PP ARG, but do not exert an agonistic effect on PPARG. Compounds of the invention can be used for treatment of conditions in patients wherein PPARG plays a role, such as diabetes or obesity. Methods of preparation of the compounds, bioassay methods for evaluating compounds of the invention as non-agonistic PPARG binding compounds, and pharmaceutical compositions are also provided.</p>
申请公布号 WO2013078237(A1) 申请公布日期 2013.05.30
申请号 WO2012US66123 申请日期 2012.11.20
申请人 RIPKA, AMY S.;SAUNDERS, JEFFREY O. 发明人 RIPKA, AMY S.;SAUNDERS, JEFFREY O.;KAMENECKA, THEODORE MARK;GRIFFIN, PATRICK R.
分类号 A61K31/00 主分类号 A61K31/00
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