发明名称 |
NOTCH1 BINDING AGENTS AND METHODS OF USE THEREOF |
摘要 |
<p>The present invention relates to Notch1 binding agents and methods of using the agents for treating diseases, such as hematologic cancers. The present invention provides antibodies that specifically bind to a non-ligand binding membrane proximal region of the extracellular domain of human Notch1. The present invention further provides methods of using agents that inhibit Notch1 activity for treating cancer. Also described are methods of treating hematologic cancers comprising administering a therapeutically effective amount of a binding agent or antibody of the present invention to a subject having a hematologic cancer such as T-cell lymphoblastic leukemia.</p> |
申请公布号 |
EP2523682(A4) |
申请公布日期 |
2013.05.29 |
申请号 |
EP20110733378 |
申请日期 |
2011.01.13 |
申请人 |
ONCOMED PHARMACEUTICALS, INC. |
发明人 |
VAN DER HORST, EDWARD, THEIN HTUN |
分类号 |
A61K39/00;A61P35/00;A61P35/02;C07K16/00;C07K16/28 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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