METFORMIN-GABA SALT AND THE DERIVATIVES THEREOF, METHODS OF PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

摘要

PURPOSE: A metformin-gaba salt and the derivatives thereof are provided to have excellent treating effect for metabolic disease and diabetes and to suppress growth of cancer cells by having excellent AMPK activation effect. CONSTITUTION: A metformin-gaba salt and the derivatives thereof are represented by chemical formula 1. A manufacturing method thereof comprises a step of conduct a reaction of metformin hydrochloride represented by chemical formula 2, water, organic solvent, or a mixture solvent under the presence of a base, to manufacture a metformin glass base represented by chemical formula 3; and a step of conducting a reaction of the manufactured metformin glass base and gaba or a derivative thereof represented by chemical formula 4 or chemical formula 5, under the presence of water, organic solvent, or a mixture solvent thereof.