| 摘要 |
FIELD: chemistry.SUBSTANCE: in order to reduce content of dimers in a composition which contains a factor VII polypeptide or a version of factor VII polypeptide, pH of said composition is brought to a value ranging from 5 to 10.0; the composition is heated to temperature ranging from 20°C to 50°C for 10 minutes to 72 hours, followed by cooling to temperature not higher than 5°C.EFFECT: low dimer content in a factor VII polypeptide composition by heat treatment.8 cl, 4 dwg, 3 ex |
