Auto-recognizing therapeutic R/DNA chimeric nanoparticles (R/DNA NP) are described that are pairs of DNA/RNA hybrids where the DNA molecules have complementary toehold sequences that promote the re- association of the R/DNA NPs when mixed resulting in the formation of RNA/RNA duplexes that act as siRNAs.
申请公布号
CA2856117(A1)
申请公布日期
2013.05.23
申请号
CA20122856117
申请日期
2012.11.19
申请人
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES
发明人
SHAPIRO, BRUCE ALLEN;AFONIN, KIRILL ANDREEVICH;VIARD, MATHIAS DENIS;BINDEWALD, ECKART H.U.
