| 发明名称 |
METHOD FOR TREATING AUTOIMMUNE DISEASE USING TACI-IG FUSION MOLECULE |
| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide methods and compositions for treatment of autoimmune diseases, including rheumatoid arthritis, comprising administering to a patient in need of such treatment a TACI-Ig fusion molecule. <P>SOLUTION: In one embodiment, the TACI-Ig fusion molecule is administered in amount sufficient to slow, suppress or inhibit proliferation-inducing functions of BIyS and APRIL. The methods for treatment of rheumatoid arthritis in a patient comprises administering to the patient a composition comprising a fusion molecule comprising: (i) TACI extracellular domain or fragment thereof which binds BIyS; and (ii) a human immunoglobulin-constant domain in an amount effective to treat the arthritis. <P>COPYRIGHT: (C)2013,JPO&INPIT |
| 申请公布号 |
JP2013100313(A) |
申请公布日期 |
2013.05.23 |
| 申请号 |
JP20130000231 |
申请日期 |
2013.01.04 |
| 申请人 |
ARES TRADING SA;ZYMOGENETICS INC |
发明人 |
BROLY HERVE;BUSBY SHARON;GROSS JANE;VISICH JENNIFER;NESTOROV IVAN |
| 分类号 |
A61K38/00;A61K31/198;A61K31/42;A61K31/4706;A61K31/519;A61K31/52;A61K31/573;A61K31/65;A61K33/24;A61K39/395;A61K45/00;A61P19/02;A61P29/00;A61P37/06;A61P43/00;C07K14/715;C07K16/00;C07K19/00 |
主分类号 |
A61K38/00 |
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