摘要 |
The present invention regards methods and/or compositions related to Natural Killer T cells that are engineered to harbor an expression construct that encodes IL-2, IL-4, IL-7, and/or IL-15 and additionally or alternatively comprise a chimeric antigen receptor (CAR). In specific embodiments, the CAR is a CAR that targets the GD2 antigen, for example in neuroblastoma. |
申请人 |
BAYLOR COLLEGE OF MEDICINE;METELITSA, LEONID, S.;LIU, DAOFENG;DOTTI, GIANPIETRO;HECZEY, ANDRAS |
发明人 |
METELITSA, LEONID, S.;LIU, DAOFENG;DOTTI, GIANPIETRO;HECZEY, ANDRAS |