发明名称 |
Tetrazole-substituted arylamides |
摘要 |
Compounds of the formula I:
or a pharmaceutically acceptable salt thereof, wherein, R 1 is optionally substituted tetrazolyl, R 2 is optionally substituted phenyl, optionally substituted pyridinyl or optionally substituted thienyl, and R 3 , R 4 , R 5 and R 6 are as defined herein. Also provided are methods of using the compounds for treating diseases mediated by a P2X 3 and/or a P2X 2/3 receptor antagonist and methods of making the compounds. |
申请公布号 |
EP2592070(A3) |
申请公布日期 |
2013.05.22 |
申请号 |
EP20120194476 |
申请日期 |
2007.06.18 |
申请人 |
F. HOFFMANN-LA ROCHE AG |
发明人 |
CHEN, LI;DILLON, MICHAEL P.;FENG, LICHUN;HAWLEY, RONALD CHARLES;YANG, MINMIN |
分类号 |
C07D257/04;A61K31/382;A61K31/397;A61K31/41;A61K31/4155;A61K31/438;A61K31/5377;A61K31/541;A61P1/00;A61P13/00;A61P29/00;C07D401/10;C07D403/10;C07D403/14;C07D405/12;C07D407/10;C07D413/10;C07D417/10;C07D417/12;C07D491/10;C07D498/08 |
主分类号 |
C07D257/04 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|