发明名称 |
COMPOSITION FOR INHIBITING EXPRESSION OF DLK-1 GENE |
摘要 |
PURPOSE: A composition for suppressing Dlk-1 gene expression is provided to suppress cancer cell progression induced by pref-1 expression, and to develop a cell therapeutic agent or an anticancer therapeutic agent using stem cells. CONSTITUTION: A composition for preventing or treating cancer contains an miR-143 nucleic acid molecule as an active ingredient. The molecule contains a base sequence in sequence number 1. The molecule suppresses Dlk-1 gene expression. The composition is used for treating cancer in which pref-1 is overexpressed. The cancer is selected from the group consisting of small cell lung cancer, neuroendocrine tumor, neuroblastoma, glioma, type-1 neurofibromatosis, liver cancer, kidney cancer, ovarian cancer, and acute leukemia. The molecule contains a vector for intracellular expression.
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申请公布号 |
KR20130051520(A) |
申请公布日期 |
2013.05.21 |
申请号 |
KR20110116215 |
申请日期 |
2011.11.09 |
申请人 |
UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIVERSITY |
发明人 |
KIM, SANG HOON;KIM, YOON JIN;LEE, HAK KYO;YOON, DU HAK;SEO, KANG SEOK |
分类号 |
A61K48/00;A61K31/7088;A61P35/00 |
主分类号 |
A61K48/00 |
代理机构 |
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