发明名称 |
DISPERSIBLE PHOSPHOLIPID STABILIZED MICROPARTICLES |
摘要 |
Rapidly dispersing solid dry therapeutic dosage form comprised of a water insoluble compound existing as a nanometer or micrometer particulate solid which is surface stabilized by the presence of at least one phospholipid, the particulate solid being dispersed throughout a bulking matrix. When the dosage form is introduced into an aqueous environment the bulking matrix is substantially completely dissolved within less than 2 minutes thereby releasing the water insoluble particulate solid in an unaggregated and/or unagglomerated state. The matrix is composed of a water insoluble substance or therapeutically useful water insoluble or poorly water soluble compound, a phospholipid and optionally also at least one non-ionic, anionic, cationic or amphipathic surfactant, together with a matrix or bulking agent and if needed a release agent. The volume weighted mean particle size of the water insoluble particle is 5 micrometers or less.
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申请公布号 |
CA2349203(C) |
申请公布日期 |
2013.05.21 |
申请号 |
CA19992349203 |
申请日期 |
1999.11.19 |
申请人 |
RTP PHARMA INC. |
发明人 |
PARIKH, INDU;MISHRA, AWADHESH K.;DONGA, ROBERT;VACHON, MICHAEL G. |
分类号 |
A61K9/14;A61K9/50;A01N;A61K;A61K9/16;A61K9/19;A61K9/51;A61K31/216;A61K31/496;A61K38/00;A61K38/13;A61K47/04;A61K47/10;A61K47/24;A61K47/26;A61K47/32;A61K47/34;A61K47/38;A61K47/40;A61K47/42;A61P37/06 |
主分类号 |
A61K9/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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