| 摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to chemical-pharmaceutical industry and concerns a method for preparing betulinic acid 3-sulphate disodium salt that is a biologically active substance being a complement inhibitor and being of the utmost interest for medicine. Betulinic acid is sulphated in 1,4-dioxane by the SO-dioxane complex at temperature 30-50°C for 4-5 hours; the reaction mixture is thereafter processed in 75% water-ethanol solution containing 4% sodium hydroxide to pH 7-8 to recover an end product.EFFECT: extended range of the sulphatising agent, simplified process ensured by using liquid SO.1 cl, 1 ex |
