| 摘要 |
The invention relates to iRNA agents, which preferably include a monomer in which the ribose moiety has been 5 replaced by a moiety other than ribose. The inclusion of such a monomer can allow for modulation of a property of the iRNA agent into which it is incorporated, e.g., by using the non-ribose moiety as a point to which a ligand or other entity, e.g., a lipophilic moiety, e.g., io cholesterol, is directly, or indirectly tethered. The invention also relates to methods of making and using such modified iRNA agents. WO 200I4/U9459-' w 0 teltherin attachment Point (R-2) backbone attachment Pointr airLIADRM 0 tether w G1 RH+ (LIGAND) B: Caine: R'0 N(RW)2 |
