Antigen Binding Proteins to Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9)

摘要

Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an 5 antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described. WO 2009/026558 PCT/US2008/074097 FIG. 23B 138/152 BIN 1.1 BIN 2 BIN 3 97 63 72 50 33 28 95 26 25 34 46 94 55 56 69 71 17H5.1 30B9.1 02B5.1 23B5.1 27B2.6 09H6.1 27B2.1 27B2.5 12H11. 16F2 22E2I 27A6.1 2812. 28D6.1 31G11.- 31-4 .1 18 62 4 15 112 53 53 16 1 9 11 109 25 60 134 86 73 43 1 1 r,4 IsF 1 1 1 5 90 -21 16 123 79 50 47 -37 -9 122 33 22 174 63 42 32 2Y3 0 1 19 25 -48 -16 72 5 31 190 68 76 46 -31 48 21 18 164 70 71 -8 -5 -31 97 13 - 1 153 45 51 41 24 1 2 2 612 -41 -71 64 -27 -20 122 44 61 23 -11 4 22 9 59 34 17 163 22 80 36 -34 -S 81 15 6 131 76 491 43 - 15 2 1 2 P65 -80 -98 -9 -84 -8 138 46 55 -1 -/ 2 -62 -17 49 -14 8 163 76 71 26 -30 -55 -14 -14 4 141 69 26 -18 ' 10 -101 92 1 22 213 72 59 31 n 6 -30 -41 -10 12 43 176 104 72 54 -4- " [29 1 88 22 32 164 99 75 37 - 2 8 ><9 -82 -74 30 -39 -19 71 24 17 A 5 27 -11 75 -10 -21 153 63 68 37 1 5 130 112 113 50 79 151 132 109 55 78 57 256 77 126 334 48 60 64 203 220 209 2 213 229 1 52 44 185 48 97 234 38 34 42 165 159 181 176 192 85 -42 -24 75 18 251 96 32 34 11 84 106 85 95 90 118 72 - j -63 -74 -149 -162 -152 -132 -133 -126 -101 -189 7 91 88 102 59 45 55 60 73 63 24 7 13 77 94 92 40 87 31 62 38 67 13 87 < - 1 00 87 71 76 27 36 56 46 37 43 9 1' 2 88 92 93 45 42 52 61 61 77 57 - 1 96 77 88 11 27 56 33 34 82 23 - 2 j3 702 72 89 58 -38 -5 36 33 38 23 48 13 1 4 2 584 31 34 31 70 64 84 70 68 86 34 2'2 1l 1i 1 4 40 35 21 53 60 63 76 69 85 19 1' - ' 1 40 -642 27 28 21 70 64 75 65 78 66 16 241242524 2064 3042.1586 1669 56 -29 13 67 25 6 3 5 4 6 26 68 122 109 77 110 78 70 40 99 46 28 179 31 26 36 122 95 104 101 129 86 -7 6 92 27 31 175 16 13 7 83 6 80 71 76 88 28 -9 -1 107 2 14 179 17 13 7 85 8 99 91 99 113 58 -18 -18 106 6 7 180 8 9 -6 74 64 98 95 82 100 55 -56 -17 91 16 13 175 10 14 -4 65 80 90 85 76 96 45 12 15 119 25 47 232 13 10 23 121 99 109 111 132 125 104 -37 -8 83 23 21 171 9 10 4 25 70 96 73 96 86 52 -89 -102 154 12 -76 223 42 71 33 114 77 58 130 54 176 72