发明名称 |
PHARMACOLOGICAL MODULATION OF POSITIVE AMPA RECEPTOR MODULATOR EFFECTS ON NEUROTROPHIN EXPRESSION |
摘要 |
Antagonists of group 1 metabotropic glutamate receptors (mGluR) potentiate the effect of positive AMPA receptor modulators on neurotrophin expression, such as brain-derived neurotrophic factor (BDNF). The findings described herein suggest a combinatorial approach for drug therapies, using both positive AMPA receptor modulators and mGluR antagonists, to enhance brain neurotrophism.
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申请公布号 |
US2013123248(A1) |
申请公布日期 |
2013.05.16 |
申请号 |
US201213654366 |
申请日期 |
2012.10.17 |
申请人 |
LAUTERBORN JULIE C.;GALL CHRISTINE M.;LYNCH GARY;THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
LAUTERBORN JULIE C.;GALL CHRISTINE M.;LYNCH GARY |
分类号 |
A61K45/06;A61K31/44;A61K31/5365 |
主分类号 |
A61K45/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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