发明名称 |
In vitro methods for determining an intracellular free magnesium deficiency of individuals by determining the expression level of a cellular Mg2+ transporter gene |
摘要 |
<p>An in vitro method is disclosed for determining the presence or absence of an intracellular free magnesium deficiency in a human individual by determining the expression rate of at least one cellular Mg 2+ transporter gene showing a direct correlation between its expression rate and the intracellular free magnesium ion concentration [Mg 2+ ] i in a cell sample of said individual and comparing the obtained expression rate with a reference value, wherein an increase of the expression rate relative to the reference value indicates that the individual suffers from an intracellular free magnesium deficiency. Suitable Mg 2+ transporter genes include CNNM2, SLC41A1 and SLC41A3.</p> |
申请公布号 |
EP2233588(B1) |
申请公布日期 |
2013.05.15 |
申请号 |
EP20090003909 |
申请日期 |
2009.03.18 |
申请人 |
PROTINA PHARMAZEUTISCHE GESELLSCHAFT MBH |
发明人 |
KOLISEK, MARTIN DR.;VORMANN, JUERGEN PROF. DR. |
分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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