发明名称 |
COMPOSITIONS AND METHODS FOR REMOVAL OR DESTRUCTION OF AMYLOID FIBRIL OR AMYLOID ADHESIN COMPRISING AGGREGATES |
摘要 |
<p>Methods and compositions for treating biofilms and diseases associated with amyloidosis such as Alzheimer's, Parkinson's and Huntington's disease, and Type 2 diabetes, by destroying amyloid fibrils in a two-step treatment are disclosed. The first step consists of binding to the amyloid fibril an intercalating molecule with a negatively charged group such as Congo red. The second step consists of adding metal ions, such as silver, gold(I), copper(I), palladium or lead ions or metal colloids of silver or gold, which destabilize the amyloid-dye complex. This process results in a disintegration of the fibril into peptide monomers and small aggregates of monomers.</p> |
申请公布号 |
EP2590658(A2) |
申请公布日期 |
2013.05.15 |
申请号 |
EP20110754815 |
申请日期 |
2011.07.08 |
申请人 |
KATHOLIEKE UNIVERSITEIT LEUVEN |
发明人 |
GYSEMANS, MAARTEN;SNAUWAERT, JOHAN;VAN HAESENDONCK, CHRIS |
分类号 |
A61K31/655;A61K33/24;A61K33/30;A61K33/34;A61K33/38;A61P3/10;A61P7/00;A61P9/00;A61P13/02;A61P17/02;A61P25/28;A61P27/02;A61P31/00;A61P31/04 |
主分类号 |
A61K31/655 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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