| 摘要 |
The pneumonic Mannheimiosis (Pasteurellosis) is a disease that affects ruminants in general, in cattle being a persistent and defiant problem. Nowadays, the disease has not been controlled nor prevented, since an effective biological has not been obtained. Mannheimia haemolytica is the main microbial agent associated with the development of this disease. The present invention refers to a vaccine biological, which comprises bacterium micro vesicles (MVs) isolated from a pathogen serotype A2, so as to prove the capacity thereof to awaken a suitable humoral immune response for preventing the individuals exposed to the field strains from developing pathological processes typical of the disease.
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