| 摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to a magnetic system which has a structure containing magnetic nanosized particles of formula MM?O, wherein M=Fe, Co, Ni, Zn, Mn; M=Fe, Cr, or maghemite which are functionalized by bifunctional compounds of formula R-(CH)-Rwhere n = 2-20, Ris specified in: CONHOH, CONHOR, PO(OH), PO(OH)(OR), COOH, COOR, SH, SR; Ris an external group, and is specified in: OH, NH, COOH, COOR; R is an alkyl group or an alkaline metal specified in C-alkyl and K, Na or Li, respectively). The structure also includes a polymer optionally containing a pharmacologically active molecule, and an external pharmacologically active molecule may be specified in anticancer agents, antimicrobial agents, anti-inflammatory agents, immunomodulators, molecules acting on the central nervous system or able to mark cells so as to enable the identification thereof by means of the usual diagnostic detectors. The invention also refers to a method for preparing the nanosized particles of formula MM?Owhich consists in adding a metal salt to alcohol, heating to complete solubilisation of salts, adding water to facilitate salt hydrolysis and heating to temperature 150-180°C to prepare a suspension to be then functionalised. The invention also refers to a method for preparing the magnetic system, wherein the functionalised nanoparticles and the pharmacologically active molecules are integrated into the matrix of a water-insoluble polymer, and the prepared structure is continuously and one-stage coated with adequate surfactants.EFFECT: invention aims at preparing the magnetic system suitable for hyperthermia procedures.16 cl, 4 tbl, 1 dwg, 26 ex |
