THE DEVELOPMENT OF ALLERGY THERAPEUTICS TARGETING HISTONE DEACETYLASE 3

摘要

PURPOSE: A method for developing an allergy therapeutic agent is provided to effectively develop the therapeutic agent by targeting histone deacetylase-3. CONSTITUTION: A method for measuring expression level of histone deacetylase-3(HDAC3) from a mammalian cell sample is used for providing necessary information for diagnosing allergic diseases. The method comprises a step of measuring expression level of DNA methyltrasferase-1(DNMT-1) or monocyte chemotactic protein-1(MCP-1) from the mammalian cell sample. The allergic diseases are selected from anaphylactic shock, bronchial asthma, urticaria, and pollinosis. The mammalian cell sample is selected from a tissue, serum, plasma, and sputum. The expression level of HDAC3 is measured using an antibody which specifically binds to HDAC3. A composition for diagnosing allergic diseases contains a marker for measuring expression level of HDAC3.