MINIMIZATION OF ADVERSE EXPERIENCE ASSOCIATED OXYBUTYNIN THERAPY

摘要

PROBLEM TO BE SOLVED: To provide a composition and a method for minimizing adverse drug experiences associated with an oxybutynin therapy, or minimizing a drug-induced adverse side effect of the oxybutynin therapy.

SOLUTION: Benefit from the oxybutynin therapy is given to a subject by offering a lower plasma level of an oxybutynin metabolite such as N-desethyl oxybutynin etc. presumed to contribute at least partially to some adverse drug experiences and simultaneously maintaining a sufficient plasma level of oxybutynin. Moreover, benefitial and effective treatments, by using the oxybutynin and an isomeric form of its metabolite, of the minimized incidence rate and/or severity of adverse drug experiences and a hyperactive bladder are maintained.

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