发明名称 |
METHODS OF TARGETING PTEN MUTANT DISEASES AND COMPOSITIONS THEREFOR |
摘要 |
<p>Provided herein are methods, uses and compositions for treating a patient with cancer wherein the cancer is characterized by a PTEN gene mutation, hi particular embodiments, the methods comprise administering to the patient a composition comprising a therapeutically effective amount of a PLK4 antagonist, and identifying a patient that is likely to be responsive to PLK4 antagonist therapy, if PTEN gene mutation is present.</p> |
申请公布号 |
EP2588110(A1) |
申请公布日期 |
2013.05.08 |
申请号 |
EP20110800027 |
申请日期 |
2011.07.04 |
申请人 |
UNIVERSITY HEALTH NETWORK |
发明人 |
PAN, GUOHUA;MASON, JACQUELINE M.;WEI, XIN;FEHER, MIKLOS |
分类号 |
A61K31/496;A61K31/415;A61K31/4155;A61K31/4439;A61P35/00 |
主分类号 |
A61K31/496 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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