HYALURONIC ACID CATECHOL CONJUGATE AND USE THEREOF

摘要

PURPOSE: A hyaluronic acid catechol conjugate and uses thereof are provided to easily give adhesiveness to biocompatible hyaluronic acid as well as to coat various solid surfaces with the biocompatible hyaluronic acid. CONSTITUTION: A hyaluronic acid catechol conjugate is formed by the bonding between carboxyl group of hyaluronic acid and amine group of dopamine with amide bonds. A manufacturing method of a hyaluronic acid catechol conjugate includes the following steps: a step of putting EDC(1-Ethyl-3-[3-dimethyl aminopropyl]carbodiimide Hydrochloride) and NHS(N-hydroxysuccinimide) into a mixture solution of hyaluronic acid and dopamine each with the same equivalent as a dopamine equivalent; a step of allowing the synthesized material to react at pH 2-7 for 2-18 hours; and a step of refining the synthesized material at pH 2-7.