发明名称 |
Delivery system for cytotoxic drugs by bispecific antibody pretargeting |
摘要 |
The present invention relates to methods and compositions for pretargeting delivery of therapeutic agents. In preferred embodiments, the pretargeting method comprises: a) administering a bispecific antibody with a first binding site for a disease-associated antigen and a hapten on a targetable construct; b) administering a targetable construct comprising at least one therapeutic agent. In preferred embodiments, the bispecific antibody is made by the dock-and-lock (DNL) technique. In a more preferred embodiment, the targetable construct comprises one or more SN-38 moieties. |
申请公布号 |
US8435539(B2) |
申请公布日期 |
2013.05.07 |
申请号 |
US20100964132 |
申请日期 |
2010.12.09 |
申请人 |
MCBRIDE WILLIAM J.;D'SOUZA CHRISTOPHER A.;CHANG CHIEN-HSING;GOLDENBERG DAVID M.;IMMUNOMEDICS, INC. |
发明人 |
MCBRIDE WILLIAM J.;D'SOUZA CHRISTOPHER A.;CHANG CHIEN-HSING;GOLDENBERG DAVID M. |
分类号 |
A61K39/385;A61K38/04;A61K51/08;C07B41/08;C08G59/00 |
主分类号 |
A61K39/385 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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