发明名称 NOVEL PEPTIDE COMPLEX AND HYBRID COMPLEX THEREOF, AND USE OF SAID HYBRID COMPLEX
摘要 <p>The present invention provides a means for delivering a substance of interest into a cell, which, even when the substance of interest is a protein, can introduce the protein into a cell with high efficiency regardless of the type of the protein, enables a given function of the protein to be exerted without inhibiting the function after the introduction of the protein into the cell, and does not use any metal that may affect a living body. A peptide complex [A] according to the present invention is characterized by comprising a leucine zipper peptide [LZ(K)] comprising the amino acid sequence represented by SEQ ID NO: 1: N'-EYQALKKKVAQLKAKNQALKKKVAQLKHK-C' or the like or a leucine zipper peptide [LZ(E)] comprising the amino acid sequence represented by SEQ ID NO: 2: N'-EYQALEKEVAQLEAENQALEKEVAQLEHE-C' or the like and an intracellular invasion peptide [CPP] linked to the leucine zipper peptide.</p>
申请公布号 WO2013061818(A1) 申请公布日期 2013.05.02
申请号 WO2012JP76654 申请日期 2012.10.16
申请人 NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY 发明人 KITAMATSU, MIZUKI;MICHIUE, HIROYUKI;WANG, FEIFEI;NAKASHIMA, MAMI;OHTSUKI, TAKASHI
分类号 C07K19/00;A61K38/00;A61K47/42;A61K47/48;A61K49/00;C07K14/47 主分类号 C07K19/00
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