发明名称 |
NOVEL PEPTIDE COMPLEX AND HYBRID COMPLEX THEREOF, AND USE OF SAID HYBRID COMPLEX |
摘要 |
<p>The present invention provides a means for delivering a substance of interest into a cell, which, even when the substance of interest is a protein, can introduce the protein into a cell with high efficiency regardless of the type of the protein, enables a given function of the protein to be exerted without inhibiting the function after the introduction of the protein into the cell, and does not use any metal that may affect a living body. A peptide complex [A] according to the present invention is characterized by comprising a leucine zipper peptide [LZ(K)] comprising the amino acid sequence represented by SEQ ID NO: 1: N'-EYQALKKKVAQLKAKNQALKKKVAQLKHK-C' or the like or a leucine zipper peptide [LZ(E)] comprising the amino acid sequence represented by SEQ ID NO: 2: N'-EYQALEKEVAQLEAENQALEKEVAQLEHE-C' or the like and an intracellular invasion peptide [CPP] linked to the leucine zipper peptide.</p> |
申请公布号 |
WO2013061818(A1) |
申请公布日期 |
2013.05.02 |
申请号 |
WO2012JP76654 |
申请日期 |
2012.10.16 |
申请人 |
NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY |
发明人 |
KITAMATSU, MIZUKI;MICHIUE, HIROYUKI;WANG, FEIFEI;NAKASHIMA, MAMI;OHTSUKI, TAKASHI |
分类号 |
C07K19/00;A61K38/00;A61K47/42;A61K47/48;A61K49/00;C07K14/47 |
主分类号 |
C07K19/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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