The invention provides a genetically modified non-human animal that comprises in its genome unrearranged T cell receptor variable gene loci, as well as non-human embryos, cells, and tissues comprising the same. Also provided are constructs for making said genetically mod- ified non-human animal and methods of making the same. Various methods of using the genetically modified non-human animal are also provided.
申请公布号
WO2013063361(A1)
申请公布日期
2013.05.02
申请号
WO2012US62065
申请日期
2012.10.26
申请人
REGENERON PHARMACEUTICALS, INC.
发明人
MACDONALD, LYNN;MURPHY, ANDREW, J.;MCWHIRTER, JOHN;TU, NAXIN;VORONINA, VERA;GURER, CAGAN;MEAGHER, KAROLINA;STEVENS, SEAN