Antagonists of IL-6 to prevent or treat cachexia, weakness, fatigue and/or fever

摘要

Abstract The present invention is directed to therapeutic methods using antibodies and fragments thereof having binding specificity for IL-6 to prevent or treat cachexia, fever, weakness and/or fatigue in a patient in need thereof. In preferred embodiments, the anti- IL-6 antibodies will be humanized and/or will be aglycosylated. Also, in preferred embodiments these patients will comprise those exhibiting (or at risk of developing) an elevated serum C-reactive protein level. In another preferred embodiment, the patient's survivability or quality of life will preferably be improved. Cr- Co o-C> -n -M C'-4 -D C) LU( 0j c L()L co Lf) LC) L()> U-) C> C) cli CJi C-l - (wu) ONIONIS