Fibrotic diseases are characterized by the replacement of healthy tissue with scar tissue and extracellular matrix in response to tissue damage. Here we describe the reduction of extracellular matrix (ECM) deposition, interstitial fibroblasts, interstitial volume, expression of Collagen I mRNA and protein, expression of profibrotic cytokines and macrophage infiltration by Cysteamine treatment.
申请公布号
WO2013062544(A1)
申请公布日期
2013.05.02
申请号
WO2011US57935
申请日期
2011.10.26
申请人
SEATTLE CHILDREN'S RESEARCH INSTITUTE;EDDY, ALLISON, A.;OKAMURA, DARYL, M.